Ontology highlight
ABSTRACT:
SUBMITTER: Gierten J
PROVIDER: S-EPMC7005164 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Gierten Jakob J Pylatiuk Christian C Hammouda Omar T OT Schock Christian C Stegmaier Johannes J Wittbrodt Joachim J Gehrig Jochen J Loosli Felix F
Scientific reports 20200206 1
Accurate quantification of heartbeats in fish models is an important readout to study cardiovascular biology, disease states and pharmacology. However, dependence on anaesthesia, laborious sample orientation or requirement for fluorescent reporters have hampered the use of high-throughput heartbeat analysis. To overcome these limitations, we established an efficient screening assay employing automated label-free heart rate determination of randomly oriented, non-anesthetized medaka (Oryzias lati ...[more]