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Self-reported sleep disturbance in Crohn's disease is not confirmed by objective sleep measures.


ABSTRACT: Sleep disturbance and fatigue are commonly reported among patients with Crohn's disease (CD). In this prospective study, we aimed to define sleep quality in CD patients at various disease activity states and compare to healthy controls using objective and subjective measures. A prospective observational cohort study of CD patients seen at a tertiary academic inflammatory bowel diseases (IBD) clinic was compared to healthy volunteers. CD activity was assessed using the Harvey-Bradshaw Index (HBI). Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) and objectively over 1-week using actigraphy (motion-based) and morning urinary melatonin metabolite. 121 subjects (CD patients N?=?61; controls N?=?60) completed the study. 34 had active CD (HBI?>?4). Sleep disturbance was more frequently reported by CD subjects than controls (PSQI: 57% vs. 35%, p?=?0.02) and in patients with active CD versus in remission state (PSQI 75.8% vs. 33.3%, p?

SUBMITTER: Iskandar HN 

PROVIDER: S-EPMC7005285 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Self-reported sleep disturbance in Crohn's disease is not confirmed by objective sleep measures.

Iskandar Heba N HN   Linan Emily E EE   Patel Ami A   Moore Renee R   Lasanajak Yi Y   Gyawali C Prakash CP   Sayuk Gregory S GS   Ciorba Matthew A MA  

Scientific reports 20200206 1


Sleep disturbance and fatigue are commonly reported among patients with Crohn's disease (CD). In this prospective study, we aimed to define sleep quality in CD patients at various disease activity states and compare to healthy controls using objective and subjective measures. A prospective observational cohort study of CD patients seen at a tertiary academic inflammatory bowel diseases (IBD) clinic was compared to healthy volunteers. CD activity was assessed using the Harvey-Bradshaw Index (HBI)  ...[more]

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