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Rapid and Precise Semi-Automatic Axon Quantification in Human Peripheral Nerves.

ABSTRACT: We developed a time-efficient semi-automated axon quantification method using freeware in human cranial nerve sections stained with paraphenylenediamine (PPD). It was used to analyze a total of 1238 facial and masseteric nerve biopsies. The technique was validated by comparing manual and semi-automated quantification of 129 (10.4%) randomly selected biopsies. The software-based method demonstrated a sensitivity of 94% and a specificity of 87%. Semi-automatic axon counting was significantly faster (p?

SUBMITTER: Engelmann S 

PROVIDER: S-EPMC7005293 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Rapid and Precise Semi-Automatic Axon Quantification in Human Peripheral Nerves.

Engelmann S S   Ruewe M M   Geis S S   Taeger C D CD   Kehrer M M   Tamm E R ER   Bleys R L A W RLAW   Zeman F F   Prantl L L   Kehrer A A  

Scientific reports 20200206 1

We developed a time-efficient semi-automated axon quantification method using freeware in human cranial nerve sections stained with paraphenylenediamine (PPD). It was used to analyze a total of 1238 facial and masseteric nerve biopsies. The technique was validated by comparing manual and semi-automated quantification of 129 (10.4%) randomly selected biopsies. The software-based method demonstrated a sensitivity of 94% and a specificity of 87%. Semi-automatic axon counting was significantly faste  ...[more]

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