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Synthetic and computational studies on CuI/ligand pair promoted activation of C(Aryl)-Cl bond in C-N coupling reactions.

ABSTRACT: Cu/ligand-mediated coupling reactions have been widely investigated in the recent past. However, activation of cheaper aryl chlorides is still a great limitation of these reactions. During the course of present investigations efforts have been made to develop a normal and facile CuI/ligand pair protocol for arylation of phthalimide using aryl chlorides. The protocol has also been extended for arylation of amines. On the basis of experimental and theoretical results, a catalytic cycle has also been proposed and it has been established that these reactions follow oxidative addition-reductive elimination (OA-RE) pathway. These studies have indicated that tetracoordinated [Cu(L1)(L2)]+ complex is active catalytic species in these reactions.

SUBMITTER: Gurjar KK

PROVIDER: S-EPMC7005438 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Synthetic and computational studies on CuI/ligand pair promoted activation of C(Aryl)-Cl bond in C-N coupling reactions.

Gurjar Kamlesh K KK Sharma Rajendra K RK

Heliyon 20200204 2

Cu/ligand-mediated coupling reactions have been widely investigated in the recent past. However, activation of cheaper aryl chlorides is still a great limitation of these reactions. During the course of present investigations efforts have been made to develop a normal and facile CuI/ligand pair protocol for arylation of phthalimide using aryl chlorides. The protocol has also been extended for arylation of amines. On the basis of experimental and theoretical results, a catalytic cycle has also be ...[more]

PMID: 32055723

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