Ontology highlight
ABSTRACT:
SUBMITTER: Wilcz-Villega E
PROVIDER: S-EPMC7005540 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Wilcz-Villega Ewa E Carter Edward E Ironside Alastair A Xu Ruoyan R Mataloni Isabella I Holdsworth Julie J Jones William W Moreno Béjar Rocío R Uhlik Lukas L Bentham Robert B RB Godinho Susana A SA Dalli Jesmond J Grose Richard R Szabadkai Gyorgy G Jones Louise L Hodivala-Dilke Kairbaan K Bianchi Katiuscia K
EMBO molecular medicine 20200113 2
During obesity, macrophages infiltrate the breast tissue leading to low-grade chronic inflammation, a factor considered responsible for the higher risk of breast cancer associated with obesity. Here, we formally demonstrate that breast epithelial cells acquire malignant properties when exposed to medium conditioned by macrophages derived from human healthy donors. These effects were mediated by the breast cancer oncogene IKKε and its downstream target-the serine biosynthesis pathway as demonstra ...[more]