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Beta-blockers in cirrhosis: Evidence-based indications and limitations.

ABSTRACT: Non-selective beta-blockers (NSBBs) are the mainstay of treatment for portal hypertension in the setting of liver cirrhosis. Randomised controlled trials demonstrated their efficacy in preventing initial variceal bleeding and subsequent rebleeding. Recent evidence indicates that NSBBs could prevent liver decompensation in patients with compensated cirrhosis. Despite solid data favouring NSBB use in cirrhosis, some studies have highlighted relevant safety issues in patients with end-stage liver disease, particularly with refractory ascites and infection. This review summarises the evidence supporting current recommendations and restrictions of NSBB use in patients with cirrhosis.

SUBMITTER: Rodrigues SG

PROVIDER: S-EPMC7005550 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Beta-blockers in cirrhosis: Evidence-based indications and limitations.

Rodrigues Susana G SG Mendoza Yuly P YP Bosch Jaime J

JHEP reports : innovation in hepatology 20191220 1

Non-selective beta-blockers (NSBBs) are the mainstay of treatment for portal hypertension in the setting of liver cirrhosis. Randomised controlled trials demonstrated their efficacy in preventing initial variceal bleeding and subsequent rebleeding. Recent evidence indicates that NSBBs could prevent liver decompensation in patients with compensated cirrhosis. Despite solid data favouring NSBB use in cirrhosis, some studies have highlighted relevant safety issues in patients with end-stage liver d ...[more]

PMID: 32039404

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Blunted cardiovascular effects of beta-blockers in patients with cirrhosis: Relation to severity?

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| S-EPMC9239488 | biostudies-literature

Nonselective beta blockers, hepatic decompensation, and mortality in cirrhosis: A national cohort study.

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Carvedilol versus traditional, non-selective beta-blockers for adults with cirrhosis and gastroesophageal varices.

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Using MR elastography to assess portal hypertension and response to beta-blockers in patients with cirrhosis.

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Project description:Content available: Audio Recording.

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