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Protective effect of vitamin C on chronic carbamazepine-induced reproductive toxicity in male wistar rats.

ABSTRACT: The aim of this study was to evaluate the protective effect of vitamin C on chronic carbamazepine-induced reproductive toxicity in male Wistar rats. Four groups of 10 rats were respectively exposed to distilled water (2?ml/kg), vitamin C (100?mg/kg), carbamazepine (20?mg/kg) and vitamin C followed by CBZ, after 30?min.. The regimens were given by gavage once daily for 15 weeks. The pituitary glands and testicular tissues were assayed for oxidative stress parameters, sperm characteristics, relative weight and histological changes. Sera samples were also assayed for concentration of sex hormones. The results showed that treatment with vitamin C protected against the alteration in parameters measuring oxidative changes, sex hormones, sperm characteristics, relative pituitary and testicular weight and histological changes. The study concluded that protection against CBZ-induced alteration in reproductive parameters by vitamin C was partly due to its antioxidant effect.

SUBMITTER: Akorede GJ

PROVIDER: S-EPMC7005556 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Protective effect of vitamin C on chronic carbamazepine-induced reproductive toxicity in male wistar rats.

Akorede Ganiu Jimoh GJ

Toxicology reports 20200127

The aim of this study was to evaluate the protective effect of vitamin C on chronic carbamazepine-induced reproductive toxicity in male Wistar rats. Four groups of 10 rats were respectively exposed to distilled water (2 ml/kg), vitamin C (100 mg/kg), carbamazepine (20 mg/kg) and vitamin C followed by CBZ, after 30 min.. The regimens were given by gavage once daily for 15 weeks. The pituitary glands and testicular tissues were assayed for oxidative stress parameters, sperm characteristics, relati ...[more]

PMID: 32055450

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Protective effect of vitamin C on chronic carbamazepine-induced reproductive toxicity in male wistar rats.

Publications

Protective effect of vitamin C on chronic carbamazepine-induced reproductive toxicity in male wistar rats.

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