Ontology highlight
ABSTRACT:
SUBMITTER: Vakirlis N
PROVIDER: S-EPMC7005711 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Vakirlis Nikolaos N Acar Omer O Hsu Brian B Castilho Coelho Nelson N Van Oss S Branden SB Wacholder Aaron A Medetgul-Ernar Kate K Bowman Ray W RW Hines Cameron P CP Iannotta John J Parikh Saurin Bipin SB McLysaght Aoife A Camacho Carlos J CJ O'Donnell Allyson F AF Ideker Trey T Carvunis Anne-Ruxandra AR
Nature communications 20200207 1
Recent evidence demonstrates that novel protein-coding genes can arise de novo from non-genic loci. This evolutionary innovation is thought to be facilitated by the pervasive translation of non-genic transcripts, which exposes a reservoir of variable polypeptides to natural selection. Here, we systematically characterize how these de novo emerging coding sequences impact fitness in budding yeast. Disruption of emerging sequences is generally inconsequential for fitness in the laboratory and in n ...[more]