Ontology highlight
ABSTRACT:
SUBMITTER: Takai E
PROVIDER: S-EPMC7005783 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Takai Erina E Maeda Daichi D Li Zhuo Z Kudo-Asabe Yukitsugu Y Totoki Yasushi Y Nakamura Hiromi H Nakamura Akiko A Nakamura Rumi R Kirikawa Misato M Ito Yukinobu Y Yoshida Makoto M Inoue Takamitsu T Habuchi Tomonori T Ikoma Shohei S Katoh Hiroto H Kato Mamoru M Shibata Tatsuhiro T Ishikawa Shumpei S Yachida Shinichi S Goto Akiteru A
Scientific reports 20200207 1
Recent genomic studies on cancer tissues obtained during rapid autopsy have provided insights into the clonal evolution and heterogeneity of cancer. However, post-mortem blood has not been subjected to genetic analyses in relation to cancer. We first confirmed that substantial quantities of cell-free DNA were present in the post-mortem plasma of 12 autopsy cases. Then, we focused on a pilot case of prostate cancer with multiple metastases for genetic analyses. Whole-exome sequencing of post-mort ...[more]