Ontology highlight
ABSTRACT:
SUBMITTER: Nozawa T
PROVIDER: S-EPMC7005872 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Nozawa Takashi T Sano Shunsuke S Minowa-Nozawa Atsuko A Toh Hirotaka H Nakajima Shintaro S Murase Kazunori K Aikawa Chihiro C Nakagawa Ichiro I
Nature communications 20200207 1
Invading microbial pathogens can be eliminated selectively by xenophagy. Ubiquitin-mediated autophagy receptors are phosphorylated by TANK-binding kinase 1 (TBK1) and recruited to ubiquitinated bacteria to facilitate autophagosome formation during xenophagy, but the molecular mechanism underlying TBK1 activation in response to microbial infection is not clear. Here, we show that bacterial infection increases Ca<sup>2+</sup> levels to activate TBK1 for xenophagy via the Ca<sup>2+</sup>-binding pr ...[more]