Ontology highlight
ABSTRACT:
SUBMITTER: Grunwald SA
PROVIDER: S-EPMC7005895 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Grunwald Stefanie Anke SA Popp Oliver O Haafke Stefanie S Jedraszczak Nicole N Grieben Ulrike U Saar Kathrin K Patone Giannino G Kress Wolfram W Steinhagen-Thiessen Elisabeth E Dittmar Gunnar G Spuler Simone S
Scientific reports 20200207 1
Statin-related muscle side effects are a constant healthcare problem since patient compliance is dependent on side effects. Statins reduce plasma cholesterol levels and can prevent secondary cardiovascular diseases. Although statin-induced muscle damage has been studied, preventive or curative therapies are yet to be reported. We exposed primary human muscle cell populations (n = 22) to a lipophilic (simvastatin) and a hydrophilic (rosuvastatin) statin and analyzed their expressome. Data and pat ...[more]