SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorder.
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ABSTRACT:
SUBMITTER: Salinas V
PROVIDER: S-EPMC7006183 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
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SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorder.
Salinas Valeria V Villarroel Juana J Silva Hernán H Herrera Luisa L Jerez Sonia S Zazueta Alejandra A Montes Cristián C Nieto Rodrigo R Bustamante M Leonor ML
BMC research notes 20200207 1
<h4>Objective</h4>Genetic factors underlying different personality traits are not entirely understood, particularly how genes interact to modulate their effect. We studied 76 patients diagnosed with borderline personality disorder (BPD), characterized by extreme levels of personality traits, especially neuroticism (N), in which we genotyped two polymorphisms, the 5HTTLPR of the Serotonin transporter (SERT) gene, and the Val66Met of the Brain-derived neurotrophic factor (BDNF) gene.<h4>Results</h ...[more]
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