Ontology highlight
ABSTRACT:
SUBMITTER: Watkins SM
PROVIDER: S-EPMC7006361 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Watkins Sydney M SM Ghose Debarati D Blain Joy M JM Grote Dakota L DL Luan Chi-Hao CH Clare Michael M Meganathan R R Horn James R JR Hagen Timothy J TJ
Bioorganic & medicinal chemistry letters 20190903 20
Enzymes in the methylerythritol phosphate pathway make attractive targets for antibacterial activity due to their importance in isoprenoid biosynthesis and the absence of the pathway in mammals. The fifth enzyme in the pathway, 2-C-methyl-d-erythritol-2,4-cyclodiphosphate synthase (IspF), contains a catalytically important zinc ion in the active site. A series of de novo designed compounds containing a zinc binding group was synthesized and evaluated for antibacterial activity and interaction wi ...[more]