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Overexpression of SAPCD2 correlates with proliferation and invasion of colorectal carcinoma cells.


ABSTRACT: Background:Suppressor anaphase-promoting complex domain containing 2 (SAPCD2) is a novel gene playing important roles in the initiation, invasion, and metastasis of several malignancies. However, its role in colorectal carcinoma (CRC) still remains unclear. Method:In this study, we investigated the expression and biological function of SAPCD2 in CRC. Immunohistochemistry (IHC) for SAPCD2 was performed in 410 pairs of CRC specimens and corresponding normal epithelial tissues, and in 50 adenoma tissues. Clinical pathological factors were analyzed in relation to the expression of SAPCD2. The biological functions of SAPCD2 in CRC cells and its effect on cell cycle were investigated in vitro and in vivo through gain/loss-of-function approaches. Results:IHC showed that SAPCD2 expression was significantly higher in CRC tissues compared to adenoma and normal epithelium tissues and was correlated with tumor location (p?=?0.018). SAPCD2 significantly promoted cell proliferation, migration, and invasion both in vitro and in vivo (p?

SUBMITTER: Luo Y 

PROVIDER: S-EPMC7006392 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Overexpression of SAPCD2 correlates with proliferation and invasion of colorectal carcinoma cells.

Luo Yage Y   Wang Lili L   Ran Wenwen W   Li Guangqi G   Xiao Yujing Y   Wang Xiaonan X   Zhao Han H   Xing Xiaoming X  

Cancer cell international 20200206


<h4>Background</h4>Suppressor anaphase-promoting complex domain containing 2 (SAPCD2) is a novel gene playing important roles in the initiation, invasion, and metastasis of several malignancies. However, its role in colorectal carcinoma (CRC) still remains unclear.<h4>Method</h4>In this study, we investigated the expression and biological function of SAPCD2 in CRC. Immunohistochemistry (IHC) for SAPCD2 was performed in 410 pairs of CRC specimens and corresponding normal epithelial tissues, and i  ...[more]

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