Ontology highlight
ABSTRACT:
SUBMITTER: Chen C
PROVIDER: S-EPMC7006436 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Chen Chen C Chencheng Zhang Z Cuiying Liu L Xiaokun Geng G
Frontiers in cellular neuroscience 20200131
Regulatory T cells (Tregs) play an anti-inflammatory effect to protect against ischemic stroke. Plasmacytoid dendritic cells (pDCs) can induce regulatory T cells tolerance in sterile-inflammation conditions. However, whether and how pDCs-mediated Tregs response play a part in the pathology of ischemic stroke remains unclear. In this study, we showed that pDCs were increased in the brain of middle cerebral artery occlusion (MCAO) mice. Depletion of pDCs with 120G8 exacerbated MCAO-induced brain i ...[more]