Ontology highlight
ABSTRACT:
SUBMITTER: Iarkov A
PROVIDER: S-EPMC7006457 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Iarkov Alexandre A Barreto George E GE Grizzell J Alex JA Echeverria Valentina V
Frontiers in aging neuroscience 20200131
Parkinson's disease (PD) is the second-leading cause of dementia and is characterized by a progressive loss of dopaminergic neurons in the substantia nigra alongside the presence of intraneuronal α-synuclein-positive inclusions. Therapies to date have been directed to the restoration of the dopaminergic system, and the prevention of dopaminergic neuronal cell death in the midbrain. This review discusses the physiological mechanisms involved in PD as well as new and prospective therapies for the ...[more]