Entorhinal velocity signals reflect environmental geometry.

ABSTRACT: The entorhinal cortex contains neurons that represent self-location, including grid cells that fire in periodic locations and velocity signals that encode running speed and head direction. Although the size and shape of the environment influence grid patterns, whether entorhinal velocity signals are equally influenced or provide a universal metric for self-motion across environments remains unknown. Here we report that speed cells rescale after changes to the size and shape of the environment. Moreover, head direction cells reorganize in an experience-dependent manner to align with the axis of environmental change. A knockout mouse model allows dissociation of the coordination between cell types, with grid and speed cells, but not head direction cells, responding in concert to environmenta

SUBMITTER: Munn RGK 

PROVIDER: S-EPMC7007349 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature