A Genetic Model of the Connectome.
Ontology highlight
ABSTRACT:
SUBMITTER: Barabasi DL
PROVIDER: S-EPMC7007360 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Publications
The connectomes of organisms of the same species show remarkable architectural and often local wiring similarity, raising the question: where and how is neuronal connectivity encoded? Here, we start from the hypothesis that the genetic identity of neurons guides synapse and gap-junction formation and show that such genetically driven wiring predicts the existence of specific biclique motifs in the connectome. We identify a family of large, statistically significant biclique subgraphs in the conn ...[more]
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