Ontology highlight
ABSTRACT:
SUBMITTER: Lee K
PROVIDER: S-EPMC7007363 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Lee Kwang K Claar Leslie D LD Hachisuka Ayaka A Bakhurin Konstantin I KI Nguyen Jacquelyn J Trott Jeremy M JM Gill Jay L JL Masmanidis Sotiris C SC
Nature neuroscience 20200113 2
Midbrain dopamine (DA) neurons encode both reward- and movement-related events and are implicated in disorders of reward processing as well as movement. Consequently, disentangling the contribution of DA neurons in reinforcing versus generating movements is challenging and has led to lasting controversy. In this study, we dissociated these functions by parametrically varying the timing of optogenetic manipulations in a Pavlovian conditioning task and examining the influence on anticipatory licki ...[more]