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Long-term stability of cortical population dynamics underlying consistent behavior.

ABSTRACT: Animals readily execute learned behaviors in a consistent manner over long periods of time, and yet no equally stable neural correlate has been demonstrated. How does the cortex achieve this stable control? Using the sensorimotor system as a model of cortical processing, we investigated the hypothesis that the dynamics of neural latent activity, which captures the dominant co-variation patterns within the neural population, must be preserved across time. We recorded from populations of neurons in premotor, primary motor and somatosensory cortices as monkeys performed a reaching task, for up to 2?years. Intriguingly, despite a steady turnover in the recorded neurons, the low-dimensional latent dynamics remained stable. The stability allowed reliable decoding of behavioral features for the entire timespan, while fixed decoders based directly on the recorded neural activity degraded substantially. We posit that stable latent cortical dynamics within the manifold are the fundamental building blocks underlying consistent behavioral execution.

SUBMITTER: Gallego JA

PROVIDER: S-EPMC7007364 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Long-term stability of cortical population dynamics underlying consistent behavior.

Gallego Juan A JA Perich Matthew G MG Chowdhury Raeed H RH Solla Sara A SA Miller Lee E LE

Nature neuroscience 20200106 2

Animals readily execute learned behaviors in a consistent manner over long periods of time, and yet no equally stable neural correlate has been demonstrated. How does the cortex achieve this stable control? Using the sensorimotor system as a model of cortical processing, we investigated the hypothesis that the dynamics of neural latent activity, which captures the dominant co-variation patterns within the neural population, must be preserved across time. We recorded from populations of neurons i ...[more]

PMID: 31907438

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Dataset Information

Long-term stability of cortical population dynamics underlying consistent behavior.

Publications

Long-term stability of cortical population dynamics underlying consistent behavior.

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