Ontology highlight
ABSTRACT:
SUBMITTER: Molina-Cruz A
PROVIDER: S-EPMC7007573 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Molina-Cruz Alvaro A Canepa Gaspar E GE Alves E Silva Thiago Luiz TL Williams Adeline E AE Nagyal Simardeep S Yenkoidiok-Douti Lampouguin L Nagata Bianca M BM Calvo Eric E Andersen John J Boulanger Martin J MJ Barillas-Mury Carolina C
Proceedings of the National Academy of Sciences of the United States of America 20200122 5
The surface protein Pfs47 allows <i>Plasmodium falciparum</i> parasites to survive and be transmitted by making them "undetectable" to the mosquito immune system. <i>P. falciparum</i> parasites express Pfs47 haplotypes compatible with their sympatric vectors, while those with incompatible haplotypes are eliminated by the mosquito. We proposed that Pfs47 serves as a "key" that mediates immune evasion by interacting with a mosquito receptor "the lock," which differs in evolutionarily divergent ano ...[more]