Skeletal muscle as an experimental model of choice to study tissue aging and rejuvenation.
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ABSTRACT:
SUBMITTER: Etienne J
PROVIDER: S-EPMC7007696 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Publications
Skeletal muscle as an experimental model of choice to study tissue aging and rejuvenation.
Etienne Jessy J Liu Chao C Skinner Colin M CM Conboy Michael J MJ Conboy Irina M IM
Skeletal muscle 20200207 1
Skeletal muscle is among the most age-sensitive tissues in mammal organisms. Significant changes in its resident stem cells (i.e., satellite cells, SCs), differentiated cells (i.e., myofibers), and extracellular matrix cause a decline in tissue homeostasis, function, and regenerative capacity. Based on the conservation of aging across tissues and taking advantage of the relatively well-characterization of the myofibers and associated SCs, skeletal muscle emerged as an experimental system to stud ...[more]
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