Ontology highlight
ABSTRACT:
SUBMITTER: Nastase AF
PROVIDER: S-EPMC7007966 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Nastase Anthony F AF Anand Jessica P JP Bender Aaron M AM Montgomery Deanna D Griggs Nicholas W NW Fernandez Thomas J TJ Jutkiewicz Emily M EM Traynor John R JR Mosberg Henry I HI
Journal of medicinal chemistry 20190409 8
Short-acting μ-opioid receptor (MOR) agonists have long been used for the treatment of severe, breakthrough pain. However, selective MOR agonists including fentanyl and morphine derivatives are limited clinically due to high risks of dependence, tolerance, and respiratory depression. We recently reported the development of a long-acting, bifunctional MOR agonist/δ-opioid receptor (DOR) antagonist analgesic devoid of tolerance or dependence in mice (AAH8, henceforth referred to as 2B). To address ...[more]