Dataset Information

Shedding of Yellow Fever Virus From an Imported Case in the Netherlands After Travel to Brazil.

ABSTRACT: We report yellow fever infection in a Dutch traveler returning from Brazil. Yellow fever virus (YFV) was identified in serum and urine samples over a period of 1 month. Yellow fever virus genome sequences from the patient clustered with recent Brazilian YFV and showed with limited nucleotide changes during the resolving infection.

SUBMITTER: Phan MVT

PROVIDER: S-EPMC7008093 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Shedding of Yellow Fever Virus From an Imported Case in the Netherlands After Travel to Brazil.

Phan My V T MVT Mendonca Melo Mariana M van Nood Els E Aron Georgina G Kreeft-Voermans Jolanda J C JJC Koopmans Marion P G MPG Reusken Chantal C GeurtsvanKessel Corine H CH Cotten Matthew M

Open forum infectious diseases 20200113 2

We report yellow fever infection in a Dutch traveler returning from Brazil. Yellow fever virus (YFV) was identified in serum and urine samples over a period of 1 month. Yellow fever virus genome sequences from the patient clustered with recent Brazilian YFV and showed with limited nucleotide changes during the resolving infection. ...[more]

PMID: 32055637

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Project description:The recent reemergence of yellow fever virus (YFV) in Brazil has raised serious concerns due to the rapid dissemination of the virus in the southeastern region. To better understand YFV genetic diversity and dynamics during the recent outbreak in southeastern Brazil, we generated 18 complete and nearly complete genomes from the peak of the epidemic curve from nonhuman primates (NHPs) and human infected cases across the Espírito Santo and Rio de Janeiro states. Genomic sequencing of 18 YFV genomes revealed the estimated timing, source, and likely routes of yellow fever virus transmission and dispersion during one of the largest outbreaks ever registered in Brazil. We showed that during the recent epidemic, YFV was reintroduced from Minas Gerais to the Espírito Santo and Rio de Janeiro states multiple times between 2016 and 2019. The analysis of data from portable sequencing could identify the corridor of spread of YFV. These findings reinforce the idea that continued genomic surveillance strategies can provide information on virus genetic diversity and transmission dynamics that might assist in understanding arbovirus epidemics.IMPORTANCE Arbovirus infections in Brazil, including yellow fever, dengue, zika, and chikungunya, result in considerable morbidity and mortality and are pressing public health concerns. However, our understanding of these outbreaks is hampered by the limited availability of genomic data. In this study, we investigated the genetic diversity and spatial distribution of YFV during the current outbreak by analyzing genomic data from areas in southeastern Brazil not covered by other previous studies. To gain insights into the routes of YFV introduction and dispersion, we tracked the virus by sequencing YFV genomes sampled from nonhuman primates and infected patients from the southeastern region. Our study provides an understanding of how YFV initiates transmission in new Brazilian regions and illustrates that genomics in the field can augment traditional approaches to infectious disease surveillance and control.

Dataset Information

Shedding of Yellow Fever Virus From an Imported Case in the Netherlands After Travel to Brazil.

Publications

Shedding of Yellow Fever Virus From an Imported Case in the Netherlands After Travel to Brazil.

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