Ontology highlight
ABSTRACT:
SUBMITTER: Baker JV
PROVIDER: S-EPMC7008475 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Baker Jason V JV Wolfson Julian J Peterson Tess T Mooberry Micah M Gissel Matthew M Mystakelis Harry H Henderson Michael W MW Garcia-Myers Kelly K Rhame Frank S FS Schacker Timothy W TW Brummel-Ziedins Kathleen E KE Sereti Irini I Key Nigel S NS Tracy Russell P RP
Open forum infectious diseases 20200201 2
<h4>Background</h4>Coagulation activity among persons with HIV is associated with end-organ disease risk, but the pathogenesis is not well characterized. We tested a hypothesis that hypercoagulation contributes to disease risk, in part, via upregulation of inflammation.<h4>Methods</h4>Treatment effects of edoxaban (30 mg), a direct factor Xa inhibitor, vs placebo were investigated in a randomized, double-blind crossover trial among participants with HIV and viral suppression and D-dimer levels ≥ ...[more]