Ontology highlight
ABSTRACT:
SUBMITTER: Kato H
PROVIDER: S-EPMC7010021 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Life science alliance 20200206 3
Mitochondria play a central role in the function of brown adipocytes (BAs). Although mitochondrial biogenesis, which is indispensable for thermogenesis, is regulated by coordination between nuclear DNA transcription and mitochondrial DNA transcription, the molecular mechanisms of mitochondrial development during BA differentiation are largely unknown. Here, we show the importance of the ER-resident sensor PKR-like ER kinase (PERK) in the mitochondrial thermogenesis of brown adipose tissue. Durin ...[more]