Risky behaviors and Parkinson disease: A mendelian randomization study.
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ABSTRACT: Objective
To examine causal associations between risky behavior phenotypes and Parkinson disease using a mendelian randomization approach.Methods
We used 2-sample mendelian randomization to generate unconfounded estimates using summary statistics from 2 independent, large meta-analyses of genome-wide association studies on risk-taking behaviors (n = 370,771-939,908) and Parkinson disease (cases n = 9,581, controls n = 33,245). We used the inverse variance weighted method as the main method for judging causality.Results
Our results support a strong protective association between the tendency to smoke and Parkinson disease (odds ratio [OR] 0.714 per log odds of ever smoking, 95% confidence interval [CI] 0.568-0.897, p = 0.0041, Cochran Q test p = 0.238; I 2 index 6.3%). Furthermore, we observed risk association trends between automobile speed propensity and the number of sexual partners and Parkinson disease after removal of overlapping loci with other risky traits (OR 1.986 for each 1-SD increase in normalized automobile speed propensity, 95% CI 1.215-3.243, p = 0.0066; OR 1.635 for each 1-SD increase in number of sexual partners, 95% CI 1.165-2.293, p = 0.0049).Conclusion
These findings provide support for a causal relationship between general risk tolerance and Parkinson disease and may provide new insights into the pathogenic mechanisms leading to the development of Parkinson disease.
SUBMITTER: Grover S
PROVIDER: S-EPMC7010323 | biostudies-literature |
REPOSITORIES: biostudies-literature
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