Ontology highlight
ABSTRACT:
SUBMITTER: Kaczmarczyk A
PROVIDER: S-EPMC7010744 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Kaczmarczyk Andreas A Hempel Antje M AM von Arx Christoph C Böhm Raphael R Dubey Badri N BN Nesper Jutta J Schirmer Tilman T Hiller Sebastian S Jenal Urs U
Nature communications 20200210 1
Bacteria adapt their growth rate to their metabolic status and environmental conditions by modulating the length of their G1 period. Here we demonstrate that a gradual increase in the concentration of the second messenger c-di-GMP determines precise gene expression during G1/S transition in Caulobacter crescentus. We show that c-di-GMP stimulates the kinase ShkA by binding to its central pseudo-receiver domain, activates the TacA transcription factor, and initiates a G1/S-specific transcription ...[more]