Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age.
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ABSTRACT:
SUBMITTER: Harris SE
PROVIDER: S-EPMC7010796 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Publications
Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age.
Harris Sarah E SE Cox Simon R SR Bell Steven S Marioni Riccardo E RE Prins Bram P BP Pattie Alison A Corley Janie J Muñoz Maniega Susana S Valdés Hernández Maria M Morris Zoe Z John Sally S Bronson Paola G PG Tucker-Drob Elliot M EM Starr John M JM Bastin Mark E ME Wardlaw Joanna M JM Butterworth Adam S AS Deary Ian J IJ
Nature communications 20200210 1
Identifying biological correlates of late life cognitive function is important if we are to ascertain biomarkers for, and develop treatments to help reduce, age-related cognitive decline. Here, we investigated the associations between plasma levels of 90 neurology-related proteins (Olink® Proteomics) and general fluid cognitive ability in the Lothian Birth Cohort 1936 (LBC1936, N = 798), Lothian Birth Cohort 1921 (LBC1921, N = 165), and the INTERVAL BioResource (N = 4451). In the LBC1936, 22 of ...[more]
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