Ontology highlight
ABSTRACT:
SUBMITTER: Wooff Y
PROVIDER: S-EPMC7010818 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Wooff Yvette Y Fernando Nilisha N Wong Josephine H C JHC Dietrich Catherine C Aggio-Bruce Riemke R Chu-Tan Joshua A JA Robertson Avril A B AAB Doyle Sarah L SL Man Si Ming SM Natoli Riccardo R
Scientific reports 20200210 1
Activation of the inflammasome is involved in the progression of retinal degenerative diseases, in particular, in the pathogenesis of Age-Related Macular Degeneration (AMD), with NLRP3 activation the focus of many investigations. In this study, we used genetic and pharmacological approaches to explore the role of the inflammasome in a mouse model of retinal degeneration. We identify that Casp1/11<sup>-/-</sup> mice have better-preserved retinal function, reduced inflammation and increased photor ...[more]