Ontology highlight
ABSTRACT:
SUBMITTER: Haynes VR
PROVIDER: S-EPMC7011014 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Haynes Vanessa R VR Michael Natalie J NJ van den Top Marco M Zhao Fei-Yue FY Brown Russell D RD De Souza David D Dodd Garron T GT Spanswick David D Watt Matthew J MJ
Molecular metabolism 20200109
<h4>Objectives</h4>Nutrient sensing by hypothalamic neurons is critical for the regulation of food intake and energy expenditure. We aimed to identify long- and medium-chain fatty acid species transported into the brain, their effects on energy balance, and the mechanisms by which they regulate activity of hypothalamic neurons.<h4>Methods</h4>Simultaneous blood and cerebrospinal fluid (CSF) sampling was undertaken in rats and metabolic analyses using radiolabeled fatty acid tracers were performe ...[more]