Dataset Information

Childhood Pancreatitis and Risk for Incident Diabetes in Adulthood.

ABSTRACT:

Objective

The relationship between acute pancreatitis and incident diabetes is unclear. We assessed whether a resolved single event of acute pancreatitis in childhood was associated with incident diabetes in adulthood.

Research design and methods

A nationwide, population-based study of 1,802,110 Israeli adolescents (mean age 17.4 years [range 16-20]) who were examined before compulsory military service between 1979 and 2008 and whose data were linked to the Israeli National Diabetes Registry (INDR). Resolved pancreatitis was defined as a history of a single event of acute pancreatitis with normal pancreatic function at enrollment. Logistic regression analysis was applied.

Results

Incident diabetes developed in 4.6% of subjects with resolved pancreatitis (13 of 281; none of these cases were identified as type 1 diabetes) and 2.5% among the unexposed group (44,463 of 1,801,716). Resolved acute pancreatitis was associated with incident diabetes with an odds ratio (OR) of 2.23 (95% CI 1.25-3.98) with adjustment for age, sex, and birth year. Findings persisted after further adjustments for baseline BMI and sociodemographic confounders (OR 2.10 [95% CI 1.15-3.84]). Childhood pancreatitis was associated with a diagnosis of diabetes at a younger age, with 92% of diabetes case subjects diagnosed before 40 years of age compared with 47% in the unexposed group (P = 0.002). The association accentuated when the study sample was limited to individuals of unimpaired health or normal BMI at baseline.

Conclusions

A history of acute pancreatitis in childhood with normal pancreatic function in late adolescence is a risk factor for incident type 2 diabetes, especially at young adulthood.

SUBMITTER: Bendor CD

PROVIDER: S-EPMC7011197 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Publications

Childhood Pancreatitis and Risk for Incident Diabetes in Adulthood.

Bendor Cole D CD Bardugo Aya A Zucker Inbar I Cukierman-Yaffe Tali T Lutski Miri M Derazne Estela E Shohat Tammy T Mosenzon Ofri O Tzur Dorit D Sapir Ari A Pinhas-Hamiel Orit O Kibbey Richard G RG Raz Itamar I Afek Arnon A Gerstein Hertzel C HC Tirosh Amir A Twig Gilad G

Diabetes care 20191106 1

<h4>Objective</h4>The relationship between acute pancreatitis and incident diabetes is unclear. We assessed whether a resolved single event of acute pancreatitis in childhood was associated with incident diabetes in adulthood.<h4>Research design and methods</h4>A nationwide, population-based study of 1,802,110 Israeli adolescents (mean age 17.4 years [range 16-20]) who were examined before compulsory military service between 1979 and 2008 and whose data were linked to the Israeli National Diabet ...[more]

PMID: 31694859

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Dataset Information

Childhood Pancreatitis and Risk for Incident Diabetes in Adulthood.

Objective

Research design and methods

Results

Conclusions

Publications

Childhood Pancreatitis and Risk for Incident Diabetes in Adulthood.

Similar Datasets

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