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Characterization of Triniti virus supports its reclassification in the family Peribunyaviridae.

ABSTRACT: Triniti virus (TNTV) has been isolated in Trinidad and Tobago and in Brazil. To date little is known about this virus, which is classified as an ungrouped virus within the family Togaviridae. Here, three isolates of TNTV were characterized both genetically and antigenically. The genome was shown to contain three RNA segments: small (S), medium (M) and large (L). Genome organization, protein sizes and protein motifs were similar to those of viruses in the genus Orthobunyavirus, family Peribunyaviridae. Antigenic reactivity revealed the three TNTV isolates to be closely related, but no serologic cross-reaction with other orthobunyaviruses. Morphological observation by transmission electron microscopy indicated that virus size and symmetry were compatible with those of viruses in the family Peribunyaviridae. Our serological, morphological and molecular results support the taxonomic reclassification of TNTV as a member of the genus Orthobunyavirus, family Peribunyaviridae.

SUBMITTER: Lima JA

PROVIDER: S-EPMC7011695 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Characterization of Triniti virus supports its reclassification in the family Peribunyaviridae.

Lima Juliana Abreu JA Nunes Neto Joaquim Pinto JP Castro Karoline Silva KS Travassos da Rosa Amélia Paes de Andrade APA Tesh Robert R Nunes Márcio Roberto Teixeira MRT Popov Vsevolod Leonidovich VL Vasilakis Nikos N Guzman Hilda H Widen Steven S Silva Sandro Patroca da SPD Medeiros Daniele Barbosa de Almeida DBA Cardoso Jedson Ferreira JF Martins Lívia Carício LC Azevedo Raimunda do Socorro da Silva RDSDS Vasconcelos Pedro Fernando da Costa PFDC Chiang Jannifer Oliveira JO

The Journal of general virology 20181214 2

Triniti virus (TNTV) has been isolated in Trinidad and Tobago and in Brazil. To date little is known about this virus, which is classified as an ungrouped virus within the family Togaviridae. Here, three isolates of TNTV were characterized both genetically and antigenically. The genome was shown to contain three RNA segments: small (S), medium (M) and large (L). Genome organization, protein sizes and protein motifs were similar to those of viruses in the genus Orthobunyavirus, family Peribunyavi ...[more]

PMID: 30547856

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Project description:Ancient undeciphered scripts present problems of different nature, not just tied to linguistic identification. The undeciphered Cypro-Minoan script from second millennium BCE Cyprus, for instance, currently does not have a standardized, definitive inventory of signs, and, in addition, stands divided into three separate subgroups (CM1, CM2, CM3), which have also been alleged to record different languages. However, this state of the art is not consensually accepted by the experts. In this article, we aim to apply a method that can aid to shed light on the tripartite division, to assess if it holds up against a multi-pronged, multi-disciplinary approach. This involves considerations linked to paleography (shapes of individual signs) and epigraphy (writing style tied to the support used), and crucially, deep learning-based strategies. These automatic methods, which are widely adopted in many fields such as computer vision and computational linguistics, allow us to look from an innovative perspective at the specific issues presented by ancient, poorly understood scripts in general, and Cypro-Minoan in particular. The usage of a state-of-the-art convolutional neural model that is unsupervised, and therefore does not use any prior knowledge of the script, is still underrepresented in the study of undeciphered writing systems, and helps to investigate the tripartite division from a fresh standpoint. The conclusions we reached show that: 1. the use of different media skews to a large extent the uniformity of the sign shapes; 2. the application of several neural techniques confirm this, since they highlight graphic proximity among signs inscribed on similar supports; 3. multi-stranded approaches prove to be a successful tool to investigate ancient scripts whose language is still unidentified. More crucially, these aspects, together, point in the same direction, namely the validation of a unitary, single Cypro-Minoan script, rather than the current division into three subgroups.

Dataset Information

Characterization of Triniti virus supports its reclassification in the family Peribunyaviridae.

Publications

Characterization of Triniti virus supports its reclassification in the family Peribunyaviridae.

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