Ontology highlight
ABSTRACT:
SUBMITTER: Xiong X
PROVIDER: S-EPMC7012051 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Chemical science 20191105 1
Although insulin was first purified and used therapeutically almost a century ago, there is still a need to improve therapeutic efficacy and patient convenience. A key challenge is the requirement for refrigeration to avoid inactivation of insulin by aggregation/fibrillation. Here, in an effort to mitigate this problem, we introduced a 4<sup>th</sup> disulfide bond between a C-terminal extended insulin A chain and residues near the C-terminus of the B chain. Insulin activity was retained by an a ...[more]