Unknown

Dataset Information

0

Effects of Vitamin C on the Prevention of Ischemia-Reperfusion Brain Injury: Experimental Study in Rats.


ABSTRACT: Background:Reperfusion syndrome after carotid endarterectomy is a complication associated with cerebrovascular self-regulation in a chronically hypoperfused cerebral hemisphere, leading to severe neurological damage. Vitamin C is an important antioxidant in brain metabolism that has shown some neuroprotective actions. Objective:To investigate the potential effects of vitamin C on cerebral reperfusion in comparison with placebo (saline) in rats. Methods:Male Wistar rats were divided into 3 groups: (i) Sham (n = 4), animals exposed to carotid arteries dissection without clamping; (ii) Control (n = 4), animals exposed to carotid arteries dissection without clamping; (ii) Control (n = 4), animals exposed to carotid arteries dissection without clamping; (ii) Control (. Results:Rats treated with vitamin C presented with a similar behavior as compared to the Sham group in all the three tests (p > 0.05), but it was significantly different from controls (p > 0.05), but it was significantly different from controls (p > 0.05), but it was significantly different from controls (. Conclusion:In the present study, vitamin C was associated with behavioral and motor preservation as well as decreased cerebral MDA levels after induced cerebral ischemia in rats.

SUBMITTER: de Sales KPF 

PROVIDER: S-EPMC7012208 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

altmetric image

Publications

Effects of Vitamin C on the Prevention of Ischemia-Reperfusion Brain Injury: Experimental Study in Rats.

de Sales Kelston Paulo Felice KPF   Pinto Bruno Araújo Serra BAS   Ribeiro Nathalee Liberal Xavier NLX   Melo Thamys Marinho TM   Galvão-Moreira Leonardo Victor LV   de Brito Filho Sebastião Barreto SB   Nigri Flávio F  

International journal of vascular medicine 20191215


<h4>Background</h4>Reperfusion syndrome after carotid endarterectomy is a complication associated with cerebrovascular self-regulation in a chronically hypoperfused cerebral hemisphere, leading to severe neurological damage. Vitamin C is an important antioxidant in brain metabolism that has shown some neuroprotective actions.<h4>Objective</h4>To investigate the potential effects of vitamin C on cerebral reperfusion in comparison with placebo (saline) in rats.<h4>Methods</h4>Male Wistar rats were  ...[more]

Similar Datasets

| S-EPMC6548905 | biostudies-literature
| S-EPMC4907771 | biostudies-other
2024-01-01 | GSE225105 | GEO
| S-EPMC7111146 | biostudies-literature
| S-EPMC6095484 | biostudies-literature
| S-EPMC7809046 | biostudies-literature
| S-EPMC8185668 | biostudies-literature
| S-EPMC9627377 | biostudies-literature
| S-EPMC6785449 | biostudies-literature
| S-EPMC4950396 | biostudies-literature