Ontology highlight
ABSTRACT:
SUBMITTER: Qi Y
PROVIDER: S-EPMC7012421 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Qi Yuan Y Fang Youhan Y Sinclair David R DR Guo Shangqin S Alberich-Jorda Meritxell M Lu Jun J Tenen Daniel G DG Kharas Michael G MG Pyne Saumyadipta S
PloS one 20200211 2
A new computational framework for FLow cytometric Analysis of Rare Events (FLARE) has been developed specifically for fast and automatic identification of rare cell populations in very large samples generated by platforms like multi-parametric flow cytometry. Using a hierarchical Bayesian model and information-sharing via parallel computation, FLARE rapidly explores the high-dimensional marker-space to detect highly rare populations that are consistent across multiple samples. Further it can foc ...[more]