Ontology highlight
ABSTRACT:
SUBMITTER: Bagwell J
PROVIDER: S-EPMC7012607 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Bagwell Jennifer J Norman James J Ellis Kathryn K Peskin Brianna B Hwang James J Ge Xiaoyan X Nguyen Stacy V SV McMenamin Sarah K SK Stainier Didier Yr DY Bagnat Michel M
eLife 20200129
The vertebral column or spine assembles around the notochord rod which contains a core made of large vacuolated cells. Each vacuolated cell possesses a single fluid-filled vacuole, and loss or fragmentation of these vacuoles in zebrafish leads to spine kinking. Here, we identified a mutation in the kinase gene <i>dstyk</i> that causes fragmentation of notochord vacuoles and a severe congenital scoliosis-like phenotype in zebrafish. Live imaging revealed that Dstyk regulates fusion of membranes wit ...[more]