Mechanisms underlying the response of mouse cortical networks to optogenetic manipulation.
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ABSTRACT:
SUBMITTER: Mahrach A
PROVIDER: S-EPMC7012611 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Publications
Mechanisms underlying the response of mouse cortical networks to optogenetic manipulation.
Mahrach Alexandre A Chen Guang G Li Nuo N van Vreeswijk Carl C Hansel David D
eLife 20200117
GABAergic interneurons can be subdivided into three subclasses: parvalbumin positive (PV), somatostatin positive (SOM) and serotonin positive neurons. With principal cells (PCs) they form complex networks. We examine PCs and PV responses in mouse anterior lateral motor cortex (ALM) and barrel cortex (S1) upon PV photostimulation in vivo. In ALM layer five and S1, the PV response is paradoxical: photoexcitation reduces their activity. This is not the case in ALM layer 2/3. We combine analytical c ...[more]
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