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Prevalence and risk factors of having antibodies to class I and II human leukocyte antigens in older haploidentical allograft candidates.

ABSTRACT: The effect of donor-specific anti-human leukocyte antigen (HLA) antibodies (DSAs) has been recognized as a factor in graft failure (GF) in patients who underwent umbilical cord blood transplantation (UBT), matched unrelated donor transplantation (MUDT), or haploidentical stem cell transplantation (haplo-SCT). Presently, we know little about the prevalence of and risk factors for having anti-HLA antibodies among older transplant candidates. Therefore, we analyzed 273 older patients with hematologic disease who were waiting for haplo-SCT. Among all patients, 73 (26.7%) patients had a positive panel-reactive antibody (PRA) result for class I, 38 (13.9%) for class II, and 32 (11.7%) for both. Multivariate analysis showed that females were at a higher risk for having a PRA result for class II (P?=?0.001) and for having antibodies against HLA-C and HLA-DQ. Prior pregnancy was a risk factor for having a PRA result for class I (P?

SUBMITTER: Cao LQ 

PROVIDER: S-EPMC7012824 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Prevalence and risk factors of having antibodies to class I and II human leukocyte antigens in older haploidentical allograft candidates.

Cao Le-Qing LQ   Lv Meng M   Xu Lan-Ping LP   Zhang Xiao-Hui XH   Chen Huan H   Chen Yu-Hong YH   Wang Feng-Rong FR   Han Wei W   Sun Yu-Qian YQ   Yan Chen-Hua CH   Tang Fei-Fei FF   Mo Xiao-Dong XD   Liu Kai-Yan KY   Huang Xiao-Jun XJ   Chang Ying-Jun YJ  

Scientific reports 20200211 1

The effect of donor-specific anti-human leukocyte antigen (HLA) antibodies (DSAs) has been recognized as a factor in graft failure (GF) in patients who underwent umbilical cord blood transplantation (UBT), matched unrelated donor transplantation (MUDT), or haploidentical stem cell transplantation (haplo-SCT). Presently, we know little about the prevalence of and risk factors for having anti-HLA antibodies among older transplant candidates. Therefore, we analyzed 273 older patients with hematolog  ...[more]

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