Ontology highlight
ABSTRACT:
SUBMITTER: van Harten AM
PROVIDER: S-EPMC7012863 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
van Harten Anne M AM de Boer D Vicky DV Martens-de Kemp Sanne R SR Buijze Marijke M Ganzevles Sonja H SH Hunter Keith D KD Leemans C René CR van Beusechem Victor W VW Wolthuis Rob M F RMF de Menezes Renée X RX Brakenhoff Ruud H RH
Scientific reports 20200211 1
HPV-negative head and neck squamous cell carcinomas (HNSCCs) develop in precancerous changes in the mucosal lining of the upper-aerodigestive tract. These precancerous cells contain cancer-associated genomic changes and cause primary tumors and local relapses. Therapeutic strategies to eradicate these precancerous cells are very limited. Using functional genomic screens, we identified the therapeutic vulnerabilities of premalignant mucosal cells, which are shared with fully malignant HNSCC cells ...[more]