Dataset Information

The role of environmental stress and DNA methylation in the longitudinal course of bipolar disorder.

ABSTRACT: BACKGROUND:Stressful life events influence the course of affective disorders, however, the mechanisms by which they bring about phenotypic change are not entirely known. METHODS:We explored the role of DNA methylation in response to recent stressful life events in a cohort of bipolar patients from the longitudinal PsyCourse study (n?=?96). Peripheral blood DNA methylomes were profiled at two time points for over 850,000 methylation sites. The association between impact ratings of stressful life events and DNA methylation was assessed, first by interrogating methylation sites in the vicinity of candidate genes previously implicated in the stress response and, second, by conducting an exploratory epigenome-wide association analysis. Third, the association between epigenetic aging and change in stress and symptom measures over time was investigated. RESULTS:Investigation of methylation signatures over time revealed just over half of the CpG sites tested had an absolute difference in methylation of at least 1% over a 1-year period. Although not a single CpG site withstood correction for multiple testing, methylation at one site (cg15212455) was suggestively associated with stressful life events (p?

SUBMITTER: Comes AL

PROVIDER: S-EPMC7013010 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

The role of environmental stress and DNA methylation in the longitudinal course of bipolar disorder.

Comes Ashley L AL Czamara Darina D Adorjan Kristina K Anderson-Schmidt Heike H Andlauer Till F M TFM Budde Monika M Gade Katrin K Hake Maria M Kalman Janos L JL Papiol Sergi S Reich-Erkelenz Daniela D Klöhn-Saghatolislam Farah F Schaupp Sabrina K SK Schulte Eva C EC Senner Fanny F Juckel Georg G Schmauß Max M Zimmermann Jörg J Reimer Jens J Reininghaus Eva E Anghelescu Ion-George IG Konrad Carsten C Thiel Andreas A Figge Christian C von Hagen Martin M Koller Manfred M Dietrich Detlef E DE Stierl Sebastian S Scherk Harald H Witt Stephanie H SH Sivalingam Sugirthan S Degenhardt Franziska F Forstner Andreas J AJ Rietschel Marcella M Nöthen Markus M MM Wiltfang Jens J Falkai Peter P Schulze Thomas G TG Heilbronner Urs U

International journal of bipolar disorders 20200212 1

<h4>Background</h4>Stressful life events influence the course of affective disorders, however, the mechanisms by which they bring about phenotypic change are not entirely known.<h4>Methods</h4>We explored the role of DNA methylation in response to recent stressful life events in a cohort of bipolar patients from the longitudinal PsyCourse study (n = 96). Peripheral blood DNA methylomes were profiled at two time points for over 850,000 methylation sites. The association between impact ratings of ...[more]

PMID: 32048126

Similar Datasets

Project description:The pharmacoepigenetics of antipsychotic treatment in severe mental illness is a growing area of research that aims to understand the interface between antipsychotic treatment and genetic regulation. Pharmacoepigenetics may some day assist in identifying treatment response mechanisms or become one of the components in the implementation of precision medicine. To understand the current evidence regarding the effects of antipsychotics on DNA methylation a systematic review with qualitative synthesis was performed through Pubmed, Embase and Psychinfo from earliest data to June 2019. Studies were included if they analyzed DNA methylation in an antipsychotic-treated population of patients with schizophrenia or bipolar disorder. Data extraction occurred via a standardized format and study quality was assessed. Twenty-nine studies were identified for inclusion. Study design, antipsychotic type, sample source, and methods of DNA methylation measurement varied across all studies. Eighteen studies analyzed methylation in patients with schizophrenia, four studies in patients with bipolar disorder, and seven studies in a combined sample of schizophrenia and bipolar disorder. Twenty-two studies used observational samples whereas the remainder used prospectively treated samples. Six studies assessed global methylation, five assessed epigenome-wide, and 15 performed a candidate epigenetic study. Two studies analyzed both global and gene-specific methylation, whereas one study performed a simultaneous epigenome-wide and gene-specific study. Only three genes were analyzed in more than one gene-specific study and the findings were discordant. The state of the pharmacoepigenetic literature on antipsychotic use is still in its early stages and uniform reporting of methylation site information is needed. Future work should concentrate on using prospective sampling with appropriate control groups and begin to replicate many of the novel associations that have been reported.

Dataset Information

The role of environmental stress and DNA methylation in the longitudinal course of bipolar disorder.

Publications

The role of environmental stress and DNA methylation in the longitudinal course of bipolar disorder.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets