Ontology highlight
ABSTRACT:
SUBMITTER: Liu TM
PROVIDER: S-EPMC7013236 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Liu Tong Ming TM Yildirim Ege Deniz ED Li Pin P Fang Hai Tong HT Denslin Vinitha V Kumar Vibhor V Loh Yuin Han YH Lee Eng Hin EH Cool Simon M SM Teh Bin Tean BT Hui James H JH Lim Bing B Shyh-Chang Ng N
Stem cell reports 20200130 2
The effects of ascorbate on adult cell fate specification remain largely unknown. Using our stepwise and chemically defined system to derive lateral mesoderm progenitors from human pluripotent stem cells (hPSCs), we found that ascorbate increased the expression of mesenchymal stromal cell (MSC) markers, purity of MSCs, the long-term self-renewal and osteochondrogenic capacity of hPSC-MSCs in vitro. Moreover, ascorbate promoted MSC specification in an iron-dependent fashion, but not in a redox-de ...[more]