The Role of Rho GTPases in Motility and Invasion of Glioblastoma Cells.
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ABSTRACT:
SUBMITTER: Al-Koussa H
PROVIDER: S-EPMC7013281 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
The Role of Rho GTPases in Motility and Invasion of Glioblastoma Cells.
Al-Koussa Houssam H Atat Oula El OE Jaafar Leila L Tashjian Hagop H El-Sibai Mirvat M
Analytical cellular pathology (Amsterdam) 20200131
Astrocytomas are primary malignant brain tumors that originate from astrocytes. Grade IV astrocytoma or glioblastoma is a highly invasive tumor that occur within the brain parenchyma. The Rho family of small GTPases, which includes Rac1, Cdc42, and RhoA, is an important family whose members are key regulators of the invasion and migration of glioblastoma cells. In this review, we describe the role played by the Rho family of GTPases in the regulation of the invasion and migration of glioblastoma ...[more]
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