Prediction of Protein-Protein Interaction Sites Using Convolutional Neural Network and Improved Data Sets.
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ABSTRACT:
SUBMITTER: Xie Z
PROVIDER: S-EPMC7013409 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Publications
Prediction of Protein-Protein Interaction Sites Using Convolutional Neural Network and Improved Data Sets.
Xie Zengyan Z Deng Xiaoya X Shu Kunxian K
International journal of molecular sciences 20200111 2
Protein-protein interaction (PPI) sites play a key role in the formation of protein complexes, which is the basis of a variety of biological processes. Experimental methods to solve PPI sites are expensive and time-consuming, which has led to the development of different kinds of prediction algorithms. We propose a convolutional neural network for PPI site prediction and use residue binding propensity to improve the positive samples. Our method obtains a remarkable result of the area under the c ...[more]
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