Ontology highlight
ABSTRACT:
SUBMITTER: Arcella A
PROVIDER: S-EPMC7014190 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Arcella Antonietta A Limanaqi Fiona F Ferese Rosangela R Biagioni Francesca F Oliva Maria Antonietta MA Storto Marianna M Fanelli Mirco M Gambardella Stefano S Fornai Francesco F
International journal of molecular sciences 20200120 2
Recently, several studies focused on the genetics of gliomas. This allowed identifying several germline loci that contribute to individual risk for tumor development, as well as various somatic mutations that are key for disease classification. Unfortunately, none of the germline loci clearly confers increased risk per se. Contrariwise, somatic mutations identified within the glioma tissue define tumor genotype, thus representing valid diagnostic and prognostic markers. Thus, genetic features ca ...[more]