Editing DNA Methylation in Mammalian Embryos.
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ABSTRACT:
SUBMITTER: Yamazaki T
PROVIDER: S-EPMC7014263 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Publications
Editing DNA Methylation in Mammalian Embryos.
Yamazaki Taiga T Hatano Yu Y Taniguchi Ryoya R Kobayashi Noritada N Yamagata Kazuo K
International journal of molecular sciences 20200118 2
DNA methylation in mammals is essential for numerous biological functions, such as ensuring chromosomal stability, genomic imprinting, and X-chromosome inactivation through transcriptional regulation. Gene knockout of DNA methyltransferases and demethylation enzymes has made significant contributions to analyzing the functions of DNA methylation in development. By applying epigenome editing, it is now possible to manipulate DNA methylation in specific genomic regions and to understand the functi ...[more]
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