Ontology highlight
ABSTRACT:
SUBMITTER: Petzold A
PROVIDER: S-EPMC7014809 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Petzold Axel A Lu Ching-Hua CH Groves Mike M Gobom Johan J Zetterberg Henrik H Shaw Gerry G O'Connor Sonia S
Journal of the Royal Society, Interface 20200108 162
Human proteins have not been reported to survive in free nature, at ambient temperature, for long periods. Particularly, the human brain rapidly dissolves after death due to auto-proteolysis and putrefaction. The here presented discovery of 2600-year-old brain proteins from a radiocarbon dated human brain provides new evidence for extraordinary long-term stability of non-amyloid protein aggregates. Immunoelectron microscopy confirmed the preservation of neurocytoarchitecture in the ancient brain ...[more]