Ontology highlight
ABSTRACT:
SUBMITTER: Nault R
PROVIDER: S-EPMC7014822 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Nault Rance R Bals Bryan B Teymouri Farzaneh F Black Michael B MB Andersen Melvin E ME McMullen Patrick D PD Krishnan Seetha S Kuravadi Nagesh N Paul Neetha N Kumar Santhosh S Kannan Kamala K Jayachandra K C KC Alagappan Lakshmanan L Patel Bhavesh Dhirajlal BD Bogen Kenneth T KT Gollapudi Bhaskar B BB Klaunig James E JE Zacharewski Tim R TR Bringi Venkataraman V
Toxicology and applied pharmacology 20191224
Acetamide (CAS 60-35-5) is detected in common foods. Chronic rodent bioassays led to its classification as a group 2B possible human carcinogen due to the induction of liver tumors in rats. We used a toxicogenomics approach in Wistar rats gavaged daily for 7 or 28 days at doses of 300 to 1500 mg/kg/day (mkd) to determine a point of departure (POD) and investigate its mode of action (MoA). Ki67 labeling was increased at doses ≥750 mkd up to 3.3-fold representing the most sensitive apical endpoint ...[more]