Ontology highlight
ABSTRACT:
SUBMITTER: Rbia N
PROVIDER: S-EPMC7015582 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Rbia Nadia N Bulstra Liselotte F LF Friedrich Patricia F PF Bishop Allen T AT Nijhuis Tim H J THJ Shin Alexander Y AY
Plastic and reconstructive surgery. Global open 20200121 1
The purpose of this study was to evaluate the molecular mechanisms underlying nerve repair by a decellularized nerve allograft seeded with adipose-derived mesenchymal stromal cells (MSCs) and compare it to the unseeded allograft and autograft nerve.<h4>Methods</h4>Undifferentiated MSCs were seeded onto decellularized nerve allografts and used to reconstruct a 10 mm gap in a rat sciatic nerve model. Gene expression profiles of genes essential for nerve regeneration and immunohistochemical stainin ...[more]