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ABSTRACT: Background
Severity index and plasma paraquat (PQ) concentration can predict the prognosis of patients with PQ poisoning. However, the better parameter is yet to be systematically investigated and determined. Thus, we conduct this systematic review and meta-analysis to investigate the prognostic value of severity index and plasma PQ concentration in patients with PQ poisoning.Methods
We searched PubMed, Embase, Web of Science, ScienceDirect, and Cochrane Library to identify all relevant papers that were published up to March 2019. All diagnostic studies that compared severity index and plasma PQ concentration to predict mortality in patients with PQ poisoning were enrolled in this meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) for individual trials were pooled using a random-effect model. We also aggregated heterogeneity testing, sensitivity analysis, and publication bias analysis.Results
Ultimately, seven studies involving 821 patients were included. The pooled OR with a 95% CI of severity index was 24.12 (95% CI: 9.34-62.34, P?ConclusionOverall, this study indicated that severity index and plasma PQ concentration have relatively high-prognostic value in patients with PQ poisoning, and that the sensitivity and specificity of plasma PQ concentration are superior to those of severity index.
SUBMITTER: Cao ZX
PROVIDER: S-EPMC7015625 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Cao Zong Xun ZX Zhao Yong Y Gao Jie J Feng Shun Yi SY Wu Cheng Pu CP Zhai Yan Zhao YZ Zhang Meng M Nie Shen S Li Yong Y
Medicine 20200201 6
<h4>Background</h4>Severity index and plasma paraquat (PQ) concentration can predict the prognosis of patients with PQ poisoning. However, the better parameter is yet to be systematically investigated and determined. Thus, we conduct this systematic review and meta-analysis to investigate the prognostic value of severity index and plasma PQ concentration in patients with PQ poisoning.<h4>Methods</h4>We searched PubMed, Embase, Web of Science, ScienceDirect, and Cochrane Library to identify all r ...[more]